| January 18, 2022 | ||
| Brighton & Hov… | 1 - 1 | Chelsea |
| January 16, 2022 | ||
| West Ham United | 2 - 3 | Leeds United |
| Liverpool | 3 - 0 | Brentford |
| January 15, 2022 | ||
| Aston Villa | 2 - 2 | Manchester United |
| Wolverhampton Wanderers | 3 - 1 | Southampton |
| Norwich City | 2 - 1 | Everton |
| Newcastle United | 1 - 1 | Watford |
| Manchester City | 1 - 0 | Chelsea |
| January 14, 2022 | ||
| Brighton & Hov… | 1 - 1 | Crystal Palace |
| January 12, 2022 | ||
| West Ham United | 2 - 0 | Norwich City |
| January 11, 2022 | ||
| Southampton | 4 - 1 | Brentford |
| January 3, 2022 | ||
| Manchester United | 0 - 1 | Wolverhampton Wanderers |
| January 2, 2022 | ||
| Chelsea | 2 - 2 | Liverpool |
| Leeds United | 3 - 1 | Burnley |
| Everton | 2 - 3 | Brighton & Hov… |
| Brentford | 2 - 1 | Aston Villa |
| January 1, 2022 | ||
| Crystal Palace | 2 - 3 | West Ham United |
| Watford | 0 - 1 | Tottenham Hotspur |
| Arsenal | 1 - 2 | Manchester City |
| December 30, 2021 | ||
| Manchester United | 3 - 1 | Burnley |
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