| October 18, 2021 | ||
| Arsenal | 2 - 2 | Crystal Palace |
| October 17, 2021 | ||
| Newcastle United | 2 - 3 | Tottenham Hotspur |
| Everton | 0 - 1 | West Ham United |
| October 16, 2021 | ||
| Brentford | 0 - 1 | Chelsea |
| Southampton | 1 - 0 | Leeds United |
| Norwich City | 0 - 0 | Brighton & Hov… |
| Manchester City | 2 - 0 | Burnley |
| Leicester City | 4 - 2 | Manchester United |
| Aston Villa | 2 - 3 | Wolverhampton Wanderers |
| Watford | 0 - 5 | Liverpool |
| October 3, 2021 | ||
| Liverpool | 2 - 2 | Manchester City |
| West Ham United | 1 - 2 | Brentford |
| Tottenham Hotspur | 2 - 1 | Aston Villa |
| Crystal Palace | 2 - 2 | Leicester City |
| October 2, 2021 | ||
| Brighton & Hov… | 0 - 0 | Arsenal |
| Chelsea | 3 - 1 | Southampton |
| Burnley | 0 - 0 | Norwich City |
| Leeds United | 1 - 0 | Watford |
| Wolverhampton Wanderers | 2 - 1 | Newcastle United |
| Manchester United | 1 - 1 | Everton |
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